Interaction Between Hypertension, apoE, and Cerebral White Matter Lesions
نویسندگان
چکیده
منابع مشابه
Interaction between hypertension, apoE, and cerebral white matter lesions.
BACKGROUND AND PURPOSE Cerebral white matter lesions (WMLs) are frequently found on magnetic resonance imaging scans in both cognitively intact and demented elderly persons. Vascular risk factors, especially hypertension, are related to their presence. However, not every person with vascular risk factors has WMLs, which suggests interaction with other determinants, eg, genetic factors. The epsi...
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Cerebral white matter lesions are frequently observed on magnetic resonance imaging (MRI) scans in elderly people and are associated with stroke and dementia. Elevated blood pressure is presumed one of the main risk factors, although data are almost exclusively derived from cross-sectional studies. We assessed in 10 European cohorts the relation between concurrently and previously measured bloo...
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and Stroke To the Editor: I read with interest the study by Vermeer and colleagues1 on the risk of stroke associated with MRI-defined white matter lesions (WML) in the Rotterdam Scan Study. As cerebral MRI becomes a routine diagnostic test for widening indications of neurological disorders, this study provides further data on the clinical significance of these lesions in asymptomatic elderly pe...
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In cognitively normal (CN) elderly individuals, white matter hyperintensities (WMH) are commonly viewed as a marker of cerebral small vessel disease (SVD). SVD is due to exposure to systemic vascular injury processes associated with highly prevalent vascular risk factors (VRFs) such as hypertension, high cholesterol, and diabetes. However, cerebral amyloid accumulation is also prevalent in this...
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ژورنال
عنوان ژورنال: Stroke
سال: 2004
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000125859.71051.83